P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case contr
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RESEARCH ARTICLE
Open Access
P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study Li Shen1, Tianlun Yang2, Ke Xia2, Zhiqiang Yan3* , Juanjuan Tan4, Lei Li5, Yingchun Qin6 and Wei Shi1
Abstract Background: Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet Pselectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-like transcript-1 (sTLT-1) is a new indicator. However, the relationship between these two markers and CAD, especially in acute coronary syndrome (ACS), has not been elucidated. This study aimed to investigate CD62P expression on the platelet surface and sTLT-1 expression in serum, as well as to assess their relationship with CAD. Methods: We measured the levels of CD62P and sTLT-1 in 83 patients with CAD compared to 49 controls. The association of these indicators with age, blood pressure, lipid profile, body mass index, and liver injury marker level were also examined. Results: CD62P concentration was higher in CAD patients than in the control group (P < 0.01), especially in acute myocardial infarction (AMI) patients (P < 0.01). Serum sTLT-1 concentration was higher in the AMI and unstable angina pectoris (UAP) groups than in the normal control (NC) group (P < 0.01). Conclusions: The consistency of sTLT-1 and CD62P expression levels in CAD patients indicates that sTLT-1 level, the same as CD62P, may be a new marker of platelet activation that is positively related to CAD. Keywords: Coronary artery disease, Acute myocardial infarction, CD62P, platelet P-selectin ligand, Soluble TREM-like transcript-1, Acute coronary syndromes
Background As coronary artery disease (CAD) continues to present an increasing global burden, early detection and timely management of risk factors are crucial to reduce morbidity and mortality. Platelet activation plays a crucial role in the pathogenesis of CAD [1]. Circulating activated platelets are thought to trigger ischemic * Correspondence: [email protected] 3 Central Laboratory, Fengxian Hospital Affiliated to the Southern Medical University, Shanghai, China Full list of author information is available at the end of the article
complications after angiography, angioplasty, and vascular surgery. The onset of CAD, especially in acute coronary syndrome (ACS), is closely associated with enhanced platelet adhesion and aggregation. Therefore, early detection and antiplatelet therapy are critically important for the treatment of coronary heart disease. P-selectin (CD62P) is a type of glycoprotein stored in the Weibel-Palade bodies of vascular endothelial cells and platelet α-granules. Activated CD62P is a transmembrane protein expressed on the platelet surface [2]. During platelet activation, the expression of CD62P on the surface of the cell membrane is dramatically increased,
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, wh
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