Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine
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ORIGINAL PAPER
Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet Ku-Zaifah Norsidah & Ahmad Yusof Asmadi & Ayob Azizi & Othman Faizah & Yusof Kamisah
Received: 25 April 2012 / Accepted: 21 November 2012 / Published online: 4 December 2012 # University of Navarra 2012
Abstract Oxidative stress contributes to cardiovascular diseases. We aimed to study the effects of palm tocotrienol-rich fraction (TRF) on plasma homocysteine and cardiac oxidative stress in rats fed with a highmethionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups 2–6 were fed 1 % methionine diet for 10 weeks. From week 6 onward, folate (8 mg/kg diet) or palm TRF (30, 60 and 150 mg/kg diet) was added into the diet of groups
K.-Z. Norsidah Department of Basic Medical Sciences, Kuliyyah of Medicine, International Islamic University of Malaysia, Pahang, Malaysia A. Y. Asmadi Faculty of Traditional and Complementary Medicine, Cyberjaya University College of Medical Sciences, Selangor, Malaysia
3, 4, 5 and 6. The rats were then killed. Palm TRF at 150 mg/kg and folate supplementation prevented the increase in plasma total homocysteine (4.14±0.33 and 4.30±0.26 vs 5.49±0.25 mmol/L, p
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