Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk inf
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POSTER PRESENTATION
Open Access
Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial Robert Boyle1*, Nick Brown2, Wen Chin Chiang3, Chua Mei Chien3, Michael Gold4, Jonathan Hourihane5, Jane Peake6, Patrick Quinn4, Raj Rao7, Peter Smith8, Mimi Tang9, John Ziegler10, John Warner1 From Food Allergy and Anaphylaxis Meeting 2014 Dublin, Ireland. 9-11 October 2014 Background We have for the first time evaluated whether a partially hydrolysed whey based (pHF) formula combined with specific mixture of prebiotic oligosaccharides would reduce the risk of allergic manifestations (AM) in formula-fed infants at increased risk of allergy. Methods We recruited term, healthy newborn infants from 10 centres in Australia, Singapore, England and Ireland. They had at least one parent with allergic disease and were randomised to receive a pHF-prebiotic formula (active; 432) or standard cow’s milk formula (control; 431) for the first 26 weeks of life if parents decided to stop or supplement breastfeeding < 18 weeks. 324 infants were followed up for occurrence of AM until 3-5 years (ISRCTN65195597). Primary outcome was cumulative incidence of atopic dermatitis (AD) up to 12 months in the key group of interest (KGI), which consisted of those infants that started formula < 28 days of age (active 375; control 383). Secondary and post-hoc outcomes are reported on all subjects randomised. Results In the KGI, AD developed in 93/324 (29%) infants randomised to control and 84/293 (29%) to active (OR 0.94 1 Imperial College London, London, United Kingdom Full list of author information is available at the end of the article
[95%CI 0.65-1.36]). We found no difference in AM at 3-5 years. The active group had lower serum cow’s milk (CM) IgG1 at 6 months than the control (p
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