Patents of nanomaterials related with cancer treatment applications

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RESEARCH PAPER

Patents of nanomaterials related with cancer treatment applications Despina A. Gkika & Nick Vordos & Michael Maragakis & Konstantinos E. Tilkeridis & Lykourgos Magafas & Athanasios C. Mitropoulos & George Z. Kyzas Received: 11 July 2020 / Accepted: 14 October 2020 # Springer Nature B.V. 2020

Abstract This paper reviews health-related nanomaterial patents filed in the European Patent Office. Five-year patents were examined, with a focus on cancer treatment applications. The main objective of this work is to examine key patent information in order to cover trends and determine the technological subfields that are experiencing the highest growth in cancer treatment through identifying the most commonly used nanomaterials and relationships between actors. The patenting trends indicated that key players on the field include the USA, France, Germany, the UK, and China. There is an increasing emphasis on the subject of antineoplastic agents, which is the main classification group referred by 32% of the examined patents. Gold, silica, D. A. Gkika : M. Maragakis : L. Magafas Physics Department, Complex Systems Laboratory, International Hellenic University, 65404 Kavala, Greece D. A. Gkika (*) : N. Vordos : M. Maragakis : L. Magafas Physics Department, International Hellenic University, St. Lucas, 65404 Kavala, Greece e-mail: [email protected] D. A. Gkika : A. C. Mitropoulos : G. Z. Kyzas Hephaestus Laboratory, School of Science, International Hellenic University, 65404 Kavala, Greece K. E. Tilkeridis Orthopaedic Department, Medical School, University General Hospital of Alexandroupolis, Democritus University of Thrace, St. Niarhos 1, Dragana, 68100 Alexandroupolis, Greece A. C. Mitropoulos : G. Z. Kyzas Department of Chemistry, International Hellenic University, Kavala, Greece

and platinum are the most frequently cited materials in cancer treatment inventions. The patent literature paints considerably different pictures of the cancer treatment field with respect to the collaborations, or lack thereof, between different actor types. Keywords European Patent Office . Patents . Cancer . Query . Collaborations . Nanomaterials

Introduction Patent statistics analysis is a frequently used methodology that has multiple applications, which is quite often performed in an attempt to uncover promising technologies and assess growth, or assist organizations in making informed decisions (Firat et al. 2008). Patent documents are a valuable source of information for research on a specific subject and innovation systems, provided that the relative data is vigorously investigated (Lee et al. 2011; Choi and Park 2009). It collects available statistical data and provides both simple and complex descriptive statistics through tables and graphical depictions. There is a wide range of online databases worldwide, allowing for patent analyses (PATSTAT Online (Beta) n.d.). Each country has their own patent office, but patents can also be submitted in international patent offices. The number of available patents on a subject is