Pathology of the Bile Duct
This book provides a comprehensive overview of the research on bile duct pathology, from basic theory to practical aspects, and presents the latest advances. The contributing authors extensively discuss the topic from different perspectives, including the
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Pathology of the Bile Duct
Yasuni Nakanuma Editor
Pathology of the Bile Duct
Editor Yasuni Nakanuma Department of Diagnostic Pathology Shizuoka Cancer Center Shizuoka Japan
ISBN 978-981-10-3499-2 ISBN 978-981-10-3500-5 (eBook) DOI 10.1007/978-981-10-3500-5 Library of Congress Control Number: 2017938880 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
About two to three decades ago, the diseases of the bile ducts, particularly the intrahepatic large bile duct and extrahepatic bile ducts, were mainly caused by infectious agents, gallstones, and malignancies, frequently associated with biliary obstruction, and these diseases were mainly dealt by surgeons therapeutically. However, in the recent two decades, the medical and pathological scopes of nonneoplastic and neoplastic diseases of these bile ducts have been much expanded and are now vigorously expanding. Particularly, imaging modalities and interventional and medical approaches to these biliary diseases have explosively advanced in these fields. In addition, with the emergence of several novel diseases such as IgG4-related sclerosing cholangitis and the discovery of preinvasive lesions of cholangiocarcinoma, new clinical and research approaches in biliary diseases have been explored. In addition, the discovery of peribiliary glands along the biliary tree and subsequent studies have caused diverse and exciting studies in this new field. Furthermore, several basic pathophysiologies of the biliary tree such as defense mechanisms, cellular senescence, innate immunity, and autophagy have been advanced and ar
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