Pathophysiology of Shock, Sepsis, and Organ Failure
In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflec
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Pathophysiology of Shock, Sepsis, and Organ Failure
With 540 Figures, some in Color, and 115 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Gunther Schlag, M. D. Heinz Redl, Ph. D. Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology Donaueschingenstra13e 13, A-1200 Vienna, Austria
ISBN-I3: 978-3-642-76738-8 e-ISBN-I3: 978-3-642-76736-4 DO[: [0.1007/978-3-642-76736-4
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© Springer-Verlag Berlin Heidelberg 1993 Softcover reprint ofthe hardcover 1st edition 1993 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: K +V Fotosatz GmbH, Beerfelden 23/3145-5 4 3 2 1 0 - Printed on acid-free paper
Preface
In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology. Thanks to the cooperation of a large number of experts in this field we were able to produce a
