Pediatric Liver Tumors
The field of liver tumors in children, and in particular hepatoblastoma in infants and young children, has seen tremendous therapeutic advances over recent years. This has been achieved through a much better understanding of the biology of disease, improv
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Arthur Zimmermann • Giorgio Perilongo (Editors) Marcio Malogolowkin • Dietrich von Schweinitz (Co-Editors)
Pediatric Liver Tumors
Editors Arthur Zimmermann Institute of Pathology of the University Murtenstrasse 31 3010 Berne Switzerland [email protected]
Co-Editors Marcio Malogolowkin Children’s Hospital Los Angeles Division of Hematology-Oncology 4650 Sunset Blvd., MS #54 Los Angeles CA 90027 USA [email protected]
Giorgio Perilongo Pediatric Hematology Oncology Division Pediatric Department University of Padova Via Giustiniani 3 35128 Padova Italy [email protected]
Dietrich von Schweinitz Kinderchirurgische Klinik im Dr. von Haunerschen Kinderspital Universität München Lindwurmstrasse 4 80337 München Germany [email protected]
ISBN 978-3-642-14503-2 e-ISBN 978-3-642-14504-9 DOI 10.1007/978-3-642-14504-9 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010938858 © Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudioCalamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Even though malignant liver tumors are rare in children, they have attracted interest and best effort, not only of pediatric oncologists and surgeons, but also tumor biologists and geneticists. The result is a significant improvement in our understanding of these tumors, patient’s outcome especially those with hepatoblastoma (HB). New developments in diagnostic imaging, tumor biology, pathology, surgical, and orthotopic liver transplant (OLXT) techniques and chemotherapy have contributed to the continued improvement in the survival of children with HB. The beneficial effect of post-operative adjuvant chemotherapy in patients with completely resected HB and hepatocellular carcinoma (HCC) was first documented by Evans in early 1990. However, the same chemotherapeutic regime failed to improve survival for
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