Pegfilgrastim
- PDF / 169,851 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 50 Downloads / 167 Views
1 S
Aortitis: case report A 65-year-old woman developed aortitis during prophylactic therapy with pegfilgrastim. The woman was diagnosed with stage IV pancreatic tail cancer and underwent distal pancreatectomy. Initially, she received chemotherapy with with gimeracil/oteracil/tegafur. Two years and 2 months later, she developed liver metastasis. Hence, chemotherapy with mFOLFIRINOX regimen including oxaliplatin, levofolinic acid, irinotecan and fluorouracil was initiated. She additionally received SC pegfilgrastim 3.6mg injection for prophylactic purposes [frequency not stated]. However, after 8 days, she developed fever and blood tests showed increased inflammatory reaction. Her CT scan demonstrated a soft shadow around the aortic arch leading to a diagnosis of aortitis. A possibility of infection could not be ruled. The woman received antibiotic therapy with minocycline and ceftriaxone and her symptoms improved. A month following improvement, the woman’s mFOLFIRINOX regimen was resumed. She received eight cycles of mFOLFIRINOX regimen along with eight courses of pegfilgrastim. Thereafter, an improvement in liver metastasis was observed. However, six days after the eight course of pegfilgrastim, she developed left abdominal pain with fever. Her CT scan demonstrated a soft shadow around the descending thoracic aorta. She was diagnosed with aortitis and treatment with antibiotic was initiated. Thereafter, her symptoms improved. Her blood cultures, antinuclear antibodies, and viral investigations were negative. Hence, infection and autoimmune diseases was ruled out and a diagnosis of pegfilgrastim-induced aortitis was confirmed. Miyazaki K, et al. A Case of Aortitis Caused by a Granulocyte-Colony-Stimulating Factor during Chemotherapy for Pancreatic Cancer. Gan to Kagaku Ryoho 47: 851-853, 803500178 No. 5, May 2020. Available from: URL: https://pubmed.ncbi.nlm.nih.gov/32408335/ [Japanese; summarised from a translation]
0114-9954/20/1820-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 5 Sep 2020 No. 1820
Data Loading...
