Performance of the RABBIT infection risk score in an Argentinian rheumatoid arthritis cohort
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BRIEF REPORT
Performance of the RABBIT infection risk score in an Argentinian rheumatoid arthritis cohort Rodrigo N. Garcia Salinas 1 & Maria A. Lázaro 2 & Santiago Scarafia 2 & Alejandra Cusa 2 & Maria V. Martire 3 & Nieves Capozzi 4 & Luciana Casalla 4 & Lucía Zárate 4 & María De la Vega 5 & Maria Correa 6 & Gustavo C. Casado 7 & Silvia Papasidero 8 & Silvana Perez 8 & Oscar L. Rillo 9 & Damaris Alvarez 10 & Mariana Benegas 11 & María P. Girard Bosch 3 & Karin Kirmayr 12 & Ramiro Gomez 13 Received: 23 August 2020 / Revised: 15 September 2020 / Accepted: 21 September 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Patients with rheumatic autoimmune diseases have a higher risk of infections compared with age-and sex-matched controls. In Latin America, there are no validated tools to assess the risk of serious infection. The objectives were to estimate the incidence of serious infections in a cohort of rheumatoid arthritis (RA) patients followed for 12 months and to validate the RABBIT risk score for serious infections. Patients with RA were included and followed for 12 months. Baseline sociodemographic data, comorbidities, RA characteristics, and vaccination status were recorded. The baseline RABBIT risk score was calculated. Serious infections were documented, describing site and time since enrollment. Six hundred five patients were included (13 centers). The incidence of serious infection was 5% (95% CI 3–7). The most frequent sites were respiratory and urinary (90%). Performance of RABBIT risk score: patients with no infection during follow-up had a median score of 1.2 (IQR 0.8–2.1) and patients with infection 5.1 (IQR 2.15–12.6) p 0.00001. ROC curve analysis: AUC 0.86 (95% CI 0.8–0.94), best cut-off 2.85 (sensibility 75%, specificity 85%). The incidence of serious infections was 5% during the follow-up. The RABBIT score performed excellently in our patients. Key Points • The RABBIT risk score for serious infections showed an excellent performance in a population different (Latin America) from the original one included in the German registry. • This may assist rheumatologists in selecting drugs for patients according to the individual risk of infection, in a fast and simple way.
Keywords Biological products . DMARD . Glucocorticoid . Infections . Rheumatoid arthritis
Introduction This manuscript was previously presented at the annual meeting of the American College of Rheumatology (ACR 2019). Garcia Salinas R, Lazaro M, Scarafia S, Cusa A, Capozzi N, Casalla L, Zarate L, de la Vega M, Correa M, Casado G, Papasidero S, Rillo O, Muñoz N, Benegas M, Kirmayr K, Girard Bosch M, Martire M, Gomez R. Performance of the RABBIT Infection Score in a Prospective Multicenter Cohort of Rheumatoid Arthritis Patients from Argentina [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). ACR Meeting Abstracts - https://acrabstracts.org/abstract/performanceof-the-rabbit-infectionscore-in-a-prospective-multicenter-cohort-ofrheumatoid-arthritis-patients-from-argentina/ * Rodrigo N. Garcia Salinas
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