Peripheral arterial tonometry as a method of measuring reactive hyperaemia correlates with organ dysfunction and prognos
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ORIGINAL RESEARCH
Peripheral arterial tonometry as a method of measuring reactive hyperaemia correlates with organ dysfunction and prognosis in the critically ill patient: a prospective observational study Luis Filipe Malheiro1,2,3,7 · Rita Gaio4 · Manuel Vaz da Silva5 · Sandra Martins6 · António Sarmento1,2,3 · Lurdes Santos1,2,3 Received: 2 June 2020 / Accepted: 24 August 2020 © Springer Nature B.V. 2020
Abstract Predictions of mortality may help in the selection of patients who benefit from intensive care. Endothelial dysfunction is partially responsible for many of the organic dysfunctions in critical illness. Reactive hyperaemia is a vascular response of the endothelium that can be measured by peripheral arterial tonometry (RH-PAT). We aimed to assess if reactive hyperaemia is affected by critical illness and if it correlates with outcomes. Prospective study with a cohort of consecutive patients admitted to an Intensive Care Unit. RH-PAT was accessed on admission and on the 7th day after admission. Early and late survivors were compared to non-survivors. The effect of RH-PAT variation on late mortality was studied by a logistic regression model. The association between RH-PAT and severity scores and biomarkers of organic dysfunction was investigated by multivariate analysis. 86 patients were enrolled. Mean ln(RHI) on admission was 0.580 and was significantly lower in patients with higher severity scores (p
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