Persistent Hyperprolactinemia and Bilateral Galactocele in a Male Infant
- PDF / 206,381 Bytes
- 4 Pages / 600.05 x 792 pts Page_size
- 35 Downloads / 165 Views
Case Report Persistent Hyperprolactinemia and Bilateral Galactocele in a Male Infant Paolo A. Tomasi,1, 2 Giuseppe Fanciulli,1 Tiziana Casti,3 and Giuseppe Delitala1 1 Dipartimento-Struttura
Clinica Medica-Patologia Speciale Medica, Universit`a degli Studi di Sassari, Viale San Pietro 8, 07100 Sassari, Italy 2 European Medicines Agency (EMEA), 7 Westferry Circus, London E14 4HB, UK 3 Pediatric Outpatients Clinic, AUSL 2, 07020 Buddus` o, Italy Correspondence should be addressed to Paolo A. Tomasi, [email protected] Received 21 November 2008; Accepted 27 January 2009 Recommended by Filiz Mine Cizmecioglu Galactocele is a benign breast lesion, usually occurring in nursing women. This lesion is a rare cause of breast enlargement in children. In this paper we describe the case of an infant with hyperprolactinemia (which persisted throughout 15 years of clinical observation) and bilateral galactocele. We speculate that a congenital midline defect in our patient might have impaired the normal dopaminergic inhibitory tone on pituitary lactotroph cells, thus leading to an increased prolactin secretion by the pituitary gland; this, in turn, might have favored the development of the galactocele. Copyright © 2009 Paolo A. Tomasi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Galactocele is a rare breast cyst containing milk-like material, usually observed in lactating women. This condition is rare in infants: only a handful of cases have been described [1–3]. Hyperprolactinemia is rare in children of less than 5 years; in particular, persistent isolated Prolactin (PRL) hypersecretion has never been described in infants. Here, we describe a child who, to our knowledge, is the first infant with persistent isolated hyperprolactinemia and the concomitant presence of bilateral galactocele. The child was born after caesarean section, performed at 34 weeks of gestation for both polyhydramnios and a previous caesarean delivery. Prenatal sonographic measurements and neonatal values were all around the 90th percentile. Perinatal anoxia led to admission to the neonatal intensive care unit. At physical examination, multiple congenital anomalies were present facial dysmorphism, low implant of the ears, hyperthelorism, macroglossia, a cleft soft palate, hyporeactivity, hypotonicity, muscular hypertrophy, membranous syndactily between the third and fourth left fingers. No skeletal abnormalities were present except for a relative hypoplasia of the facial bones. Electrolytes, thyroid hormones, creatine kinase, and lactate dehydrogenase values were normal. A normal 46 XY karyotype was present. A transbregmatic
cerebral sonography and an abdominal sonography did not show any abnormality. No abnormality was found by an ophthalmologic consultant. At 6 months a veloplastic repair was performed for correction of the cleft palate. At 8 months a large left inguinal
Data Loading...
