Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-
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Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trial Bálint Erőss1,2†, Zsolt Molnár1,3†, Zsolt Szakács1,4†, Noémi Zádori1,4†, Lajos Szakó1,4†, Szilárd Váncsa1,4†, Márk Félix Juhász1,4†, Klementina Ocskay1,4†, Nóra Vörhendi1,4†, Katalin Márta1,4†, Andrea Szentesi1,2,5†, Andrea Párniczky1,6†, Péter J. Hegyi1,4†, Szabolcs Kiss1,4,5,7†, Mária Földi1,4,5,7†, Fanni Dembrovszky1,4†, Anna Kanjo1,4,6†, Piroska Pázmány1,4,6†, András Varró8†, Árpád Csathó9†, Zsuzsanna Helyes4,10†, Zoltán Péterfi11†, László Czopf12†, István Kiss13†, Antal Zemplényi14,15†, Dóra Czapári1†, Eszter Hegyi1,16†, Dalma Dobszai1†, Emőke Miklós1†, Attila Márta1†, Dominika Tóth1†, Richard Farkas1†, Nelli Farkas1,17†, Béla Birkás9†, Erika Pintér4,10†, Gábor Pethő4,10†, Borbála Zsigmond6†, Andrea Sárközi6†, Anikó Nagy6† and Péter Hegyi1,2,4,5*†
Abstract Background: Early reports indicate that COVID-19 may require intensive care unit (ICU) admission in 5–26% and overall mortality can rise to 11% of the recognised cases, particularly affecting the elderly. There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. We aim to compare the effects of a World Health Organization recommendation-based education and a personalised complex preventive lifestyle intervention package (based on the same WHO recommendation) on the outcomes of the COVID-19. (Continued on next page)
* Correspondence: [email protected]; [email protected]; https://www.tm-centre.org † Bálint Erőss, Zsolt Molnár, Zsolt Szakács, Noémi Zádori, Lajos Szakó, Szilárd Váncsa, Félix Juhász, Klementina Ocskay, Nóra Vörhendi, Katalin Márta, Andrea Szentesi, Andrea Párniczky, Péter J. Hegyi, Szabolcs Kiss, Mária Földi, Fanni Dembrovszky, Anna Kanjo, Piroska Pázmány, András Varró, Árpád Csathó, Zsuzsanna Helyes, Zoltán Péterfi, László Czopf, István Kiss, Antal Zemplényi, Dóra Czapári, Eszter Hegyi, Dalma Dobszai, Emőke Miklós, Attila Márta, Dominika Tóth, Richard Farkas, Nelli Farkas, Béla Birkás, Erika Pintér, Gábor Pethő, Borbála Zsigmond, Andrea Sárközi, Anikó Nagy and Péter Hegyi contributed equally to this work. 1 Institute for Translational Medicine, Medical School, University of Pécs, Szigeti út 12, Pécs H-7624, Hungary 2 Translational Medicine Foundation, Szeged, Hungary Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If
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