Photobiomodulation reduces the impact of radiotherapy on oral health-related quality of life due to mucositis-related sy
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ORIGINAL ARTICLE
Photobiomodulation reduces the impact of radiotherapy on oral health-related quality of life due to mucositis-related symptoms in head and neck cancer patients Allisson Filipe Lopes Martins 1 & Marília Oliveira Morais 2 & Sebastião Silvério de Sousa-Neto 1 & Ana Paula Gonçalves de Jesus 1 & Tulio Eduardo Nogueira 3 & Marize Campos Valadares 4 & Nilceana Maya Aires Freitas 5 & Aline Carvalho Batista 1 & Cláudio Rodrigues Leles 3 & Elismauro Francisco Mendonça 1 Received: 15 April 2020 / Accepted: 21 October 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract To assess the effectiveness of photobiomodulation therapy (PBMT) in the oral health-related quality of life (OHRQoL) of patients with head and neck cancer undergoing radiotherapy (RT), using the Oral Health Impact Profile-14 (OHIP-14) and the Patient-Reported Oral Mucositis (OM) Symptoms Scale (PROMS), and to correlate OM degree with the PROMS and OHIP-14 scores. Forty-eight patients undergoing RT for head and neck cancer were randomly assigned into two groups: PBMT group (n = 25)—daily PBMT associated with a preventive oral care program (POCP); and control group (n = 23)—receiving POCP exclusively. OHRQoL was assessed using the PROMS and OHIP-14 questionnaires. OM degrees were classified according to the World Health Organization and the National Cancer Institute scales. Assessments were performed at the 1st, 7th, 14th, 21st, and 30th RT sessions. PBMT was effective in preventing and treating severe OM. Both groups showed increased OHRQoL impacts throughout the RT sessions; however, higher impacts were observed in the control group, mainly at the final stage of treatment (21st and 30th RT sessions). Significant correlations were found between the severity of OM and PROMS scores in the total sample and the control group at all RT periods. PROMS and OM scores were positive correlated at 14th, 21st, and 30th RT Supplementary Information The online version contains supplementary material available at https://doi.org/10.1007/s10103-02003167-z. * Elismauro Francisco Mendonça [email protected] Allisson Filipe Lopes Martins [email protected]
Cláudio Rodrigues Leles [email protected] 1
Laboratório de Patologia Oral, Faculdade de Odontologia, Universidade Federal de Goiás, Avenida Universitária Esquina com 1ª Avenida, s/n, Setor Universitário, Goiânia, Goiás 74605-220, Brazil
2
Hospital de Câncer Araújo Jorge, R. 239, 206 - Setor Universitário, Goiânia, Goiás 74175-120, Brazil
3
Departamento de Prevenção e Reabilitação Oral da Faculdade de Odontologia, Universidade Federal de Goiás, Avenida Universitária Esquina com 1ª Avenida, s/n, Setor Universitário, Goiânia, Goiás CEP 74605-220, Brazil
4
Laboratório de Farmacologia e Toxicologia Celuular, Faculdade de Farmácia, Universidade Federal de Goiás, 5ª Avenida Esquina com Rua 240, s/n, Setor Universitário, Goiânia, Goiás 74605-170, Brazil
5
Departamento de Radioterapia, Hospital de Câncer Araújo Jorge, R. 239, 206–Setor Universitário, Goiânia, Goiás 74175-120, Brazil
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