Physiological abnormalities in patients admitted with acute exacerbation of COPD: an observational study with continuous
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ORIGINAL RESEARCH
Physiological abnormalities in patients admitted with acute exacerbation of COPD: an observational study with continuous monitoring Mikkel Elvekjaer1,2,3 · Eske K. Aasvang3,6 · Rasmus M. Olsen4 · Helge B. D. Sørensen4 · Celeste M. Porsbjerg2,5,6 · Jens‑Ulrik Jensen6,7,8 · Camilla Haahr‑Raunkjær1,2,3 · Christian S. Meyhoff1,2,6 · for the WARD-Project Group Received: 29 May 2019 / Accepted: 31 October 2019 © Springer Nature B.V. 2019
Abstract Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) may rapidly require intensive care treatment. Evaluation of vital signs is necessary to detect physiological abnormalities (micro events), but patients may deteriorate between measurements. We aimed to assess if continuous monitoring of vital signs in patients admitted with AECOPD detects micro events more often than routine ward rounds. In this observational pilot study (NCT03467815), 30 adult patients admitted with AECOPD were included. Patients were continuously monitored with peripheral oxygen saturation (SpO2), heart rate, and respiratory rate during the first 4 days after admission. Hypoxaemic events were defined as decreased S pO2 for at least 60 s. Non-invasive blood pressure was also measured every 15–60 min. Clinical ward staff measured vital signs as part of Early Warning Score (EWS). Data were analysed using Fisher’s exact test or Wilcoxon rank sum test. Continuous monitoring detected episodes of SpO2
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