Pimecrolimus
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Pimecrolimus Kaposi’s varicelliform eruption in a child: case report A 2.5-year-old boy had been using pimecrolimus cream [dosage not stated] intermittently for 4 months for atopic dermatitis when he presented with a 4-day history of pruritic blisters on his nose and cheeks. For the week leading up to presentation, he had been using pimecrolimus. Cervical lymphadenopathy and fever were noted on examination; his WBC count was 14 900 and his IgE level was 74 U/mL. Tzanck smear demonstrated acantholytic multinucleated giant cells. He was positive for herpes simplex virus IgM, and Kaposi’s varicelliform eruption (KVE) was diagnosed. Pimecrolimus was withdrawn, and treatment was started with aciclovir, amoxicillin/clavulanic acid, and fusidic acid. After 7 days, his vesicular lesions had resolved. Author comment: In our case, the appearance of lesions following the continuous use of pimecrolimus cream in the past week, as well as the absence of other individuals in his environment who had had a herpes infection, and the result of the Tzanck smear have led us to believe that KVE is secondary to pimecrolimus. Canpolat F, et al. Kaposi's varicelliform eruption during treatment of atopic dermatitis with pimecrolimus cream. Turk Dermatoloji Dergisi 4: 22-24, No. 1, 803020961 Mar 2010 [Turkish; summarised from a translation] - Turkey
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Reactions 19 Jun 2010 No. 1306
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