Plasma sclerostin levels are associated with nutritional status and insulin resistance but not hormonal disturbances in
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GYNECOLOGIC ENDOCRINOLOGY AND REPRODUCTIVE MEDICINE
Plasma sclerostin levels are associated with nutritional status and insulin resistance but not hormonal disturbances in women with polycystic ovary syndrome Katarzyna Wyskida1 · Grzegorz Franik2 · Aleksander Jerzy Owczarek3 · Piotr Choręza3 · Piotr Kocełak4 · Paweł Madej2 · Jerzy Chudek4,5 · Magdalena Olszanecka‑Glinianowicz1 Received: 12 November 2019 / Accepted: 18 June 2020 © The Author(s) 2020
Abstract Objective The aim of this study was to evaluate the circulating sclerostin levels with nutritional status, insulin resistance and hormonal disturbances in women with polycystic ovary syndrome (PCOS). Patients and methods The cross-sectional study involved 98 PCOS inpatients (20 normal weight, 17 overweight and 61 obese) with stable body mass. Body composition was assessed by bioimpedance method in addition to anthropometric measurements (body mass and height). Serum/plasma concentrations of glucose, insulin (with the calculation of homeostatic model assessment insulin resistance—HOMA-IR), estradiol, total testosterone, sex hormone-binding globulin (SHBG) and sclerostin were measured. Free androgen index (FAI) and estradiol/testosterone index were calculated. Results Plasma sclerostin levels were significantly higher in obese [0.61 (interquartile range 0.53–0.77) ng/mL] than in overweight [0.53 (0.49–0.57) ng/mL] and normal weight [0.49 (0.42–0.54) ng/mL] groups. Plasma sclerostin levels were significantly higher in the subgroup with insulin resistance [0.65 (interquartile range 0.53–0.77) vs. 0.52 (0.46–0.58) ng/mL; p
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