Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis
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(2020) 36:25
ORIGINAL ARTICLE
The Egyptian Journal of Otolaryngology
Open Access
Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis Hany Samir Mostafa1*
and Essam Ezzat Ayad2
Abstract Background: Primary atrophic rhinitis (1ry AR) is a chronic nasal disease characterized by the loss of mucociliary clearance and presence of viscid secretions and dried crusts that causes a characteristic foul odor, usually bilateral. A large range of treatment modalities had been tried, yet there is still no agreement upon a curative treatment with long-lasting success. The purpose of the study was to assess the value of platelet-rich plasma as a biogenic stimulator for healing acceleration in primary atrophic rhinitis. A total of 78 cases clinically diagnosed to have primary atrophic rhinitis were included. Nasal endoscopy, Sino-Nasal Outcome Test-25 questionnaire, mucociliary clearance assessment by saccharine transit time test, and biopsy specimens were achieved before 1 month and 6 months after the application of platelet-rich plasma in group A (cases) and platelet-poor plasma in group B (controls). Results: All patients in group A showed endoscopic improvement and reduction in the incidence of the most frequently encountered symptoms before platelet-rich plasma injection including nasal crusts, 36 (92.30%); foetor, 31 (79.48%); nasal obstruction, 30 (76.92%); anosmia, 17 (43.58%); and epistaxis, 7 (17.94%) to nasal crusts, 9 (23.07%); foetor, 13 (33.33%); nasal obstruction, 14 (35.89%); anosmia, 13 (33.33%); and epistaxis, 3 (7.69%), 6 months after, and this was reflected in the reduction of the Sino-Nasal Outcome Test-25 scores which was averaged 40 before plateletrich plasma to 9, 6 months after. Similarly, the mucociliary clearance time was significantly reduced after platelet-rich plasma injection; saccharine transit time test was initially averaged at 1980 s and got reduced to 920 s, 6 months after platelet-rich plasma injection. Conclusion: The use of platelet-rich plasma as a biogenic stimulator is a possible innovative less invasive approach that can be effective in repairing tissue dystrophy through further future studies. Keywords: Primary atrophic rhinitis, Platelet-rich plasma, Mucociliary clearance, Saccharine transit time test
Background Primary atrophic rhinitis (1ry AR) is a chronic nasal mucosal disease, characterized by extensive fibrosis leading to atrophic changes of the nasal mucosa and the underlying bone of the nasal turbinates resulting in the presence of viscid secretions and dried crusts that causes a characteristic foul odor, usually bilateral [1]. It is mainly seen in Africa, Asia, Eastern Europe especially Egypt, * Correspondence: [email protected] 1 Otorhinolaryngology Department, Fayoum University, Fayoum, Egypt Full list of author information is available at the end of the article
India, Saudi Arabia, Philippines, and Poland [2, 3]. Where it can affect 0.3–1.0% of the population with special predominance in teens, and young adults show higher pre
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