Postural control in paw distance after labyrinthectomy-induced vestibular imbalance
- PDF / 587,443 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 1 Downloads / 158 Views
ORIGINAL ARTICLE
Postural control in paw distance after labyrinthectomy-induced vestibular imbalance Gyutae Kim 1
&
Nguyen Nguyen 1,2 & Kyu-Sung Kim 1,2
Received: 28 January 2020 / Accepted: 14 October 2020 # International Federation for Medical and Biological Engineering 2020
Abstract Balance control is accomplished by the anatomical link which provides the neural information for the coordination of skeletal muscles. However, there are few experimental proofs to directly show the neuroanatomical connection. Here, we examined the behavioral alterations by constructing an animal model with chemically induced unilateral labyrinthectomy (UL). In the experiment using rats (26 for UL, 14 for volume cavity, 355–498 g, male), the models were initially evaluated by the rota-rod (RR) test (21/26, 80.8%) and ocular displacement (23/26, 88.5%). The duration on the rolling rod decreased from 234.71 ± 64.25 s (4th trial before UL) to 11.81 ± 17.94 s (1st trial after UL). Also, the ocular skewed deviation (OSD) was observed in the model with left (5.79 ± 3.06°) and right lesion (3.74 ± 2.69°). Paw distance (PW) was separated as the front (FPW) and the hind side (HPW), and the relative changes of HPW (1.71 ± 1.20 cm) was larger than those of FPW (1.39 ± 1.06 cm), providing a statistical significance (p = 1.51 × 10−4, t test). Moreover, the results of the RR tests matched to those of the changing rates (18/21, 85.7%), and the changes (16/18, 88.9%) were dominantly observed in HPW (in FPW, 2/18, 11.1%). Current results indicated that the UL directly affected the changes in HPW more than those in FPW. In conclusion, the missing neural information from the peripheral vestibular system caused the abnormal posture in HPW, and the postural instability might reduce the performance during the voluntary movement shown in the RR test, identifying the relation between the walking imbalance and the unstable posture in PW. Keywords Balance . Paw distance . Posture . Voluntary movement . Unilateral labyrinthectomy
1 Introduction Accumulated neuroanatomic results indicate that the skeletal muscles receive the motor commands from the central nervous system to support the balance of posture or voluntary movement. The neural control using the commands is a complicated process, mainly constructed by the combination of visual, somatosensory, and vestibular information [1–3]. Based on the evoked body sway, center of mass or center of pressure in human and other species, these control systems
* Gyutae Kim [email protected] 1
Research Institute for Aerospace and Medicine, Inha University, JungSeok Blgd. B-501, 366 SeoHae-daero, Joong-gu, Incheon 22332, South Korea
2
Department of Otolaryngology Head & Neck Surgery, Inha University Hospital, 27 Inhang-ro, Jung-Gu, Incheon 400-711, South Korea
have been thoroughly investigated separately in visual [4, 5], somatosensory [6, 7], and vestibular sensations [8, 9]. These previous studies indicated that the balance-related motor command modified its amplitude to provide the neural information for a fas
Data Loading...
