Precision Molecular Pathology of Uterine Cancer
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer
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Michael T. Deavers Donna M. Coffey Editors
Precision Molecular Pathology of Uterine Cancer
Molecular Pathology Library Series editor Philip T. Cagle, MD
More information about this series at http://www.springer.com/series/7723
Michael T. Deavers Donna M. Coffey •
Editors
Precision Molecular Pathology of Uterine Cancer
123
Editors Michael T. Deavers Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston, TX USA
ISSN 1935-987X Molecular Pathology Library ISBN 978-3-319-57983-2 DOI 10.1007/978-3-319-57985-6
Donna M. Coffey Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston, TX USA
ISSN 1935-9888
(electronic)
ISBN 978-3-319-57985-6
(eBook)
Library of Congress Control Number: 2017943170 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Contents
Part I 1
Introduction
Endometrial Carcinoma: Precursor Lesions and Molecular Profiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Sudeshna Bandyopadhyay and Rouba Ali-Fehmi
Part II
3
Endometrial Carcinoma
2
Classification of Endometrial Carcinoma . . . . . . . . . . . . . . . . . . . . . Sigurd F. Lax
21
3
Immunohistochemical Markers in Endometrial Carcinoma . . . . . . . Bojana Djordjevic and Russell R. Broaddus
43
4
Molecular Pathology of Endometrioid Adenocarcinoma . . . . . . . . . Katherine C. Kurnit, Bojana Djordjevic and Russell R. Broaddus
65
5
The Molecular Pathology of Serous Endometrial Cancer. . . . . . . . . Mary Ellen Urick, Meghan L. Rudd and Daphne W. Bell
87
6
Uterine Clear Cell Carcinoma . . . . . . . . . . .
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