Prediction of outcomes in MCI with 123 I-IMP-CBF SPECT: a multicenter prospective cohort study
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ORIGINAL ARTICLE
Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study Kengo Ito • Etsuro Mori • Hidenao Fukuyama • Kazunari Ishii • Yukihiko Washimi Takashi Asada • Satoru Mori • Kenichi Meguro • Shin Kitamura • Haruo Hanyu • Seigo Nakano • Hiroshi Matsuda • Yasuo Kuwabara • Kazuo Hashikawa • Toshimitsu Momose • Yoshitaka Uchida • Jun Hatazawa • Satoshi Minoshima • Kenji Kosaka • Tatsuo Yamada • Yoshiharu Yonekura • J-COSMIC Study Group
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Received: 7 May 2013 / Accepted: 22 August 2013 / Published online: 6 September 2013 Ó The Japanese Society of Nuclear Medicine 2013
Abstract Objective The multicenter prospective cohort study (Japan Cooperative SPECT Study on Assessment of Mild Impairment of Cognitive Function: J-COSMIC) aimed to examine the value of 123I-N-isopropyl-4-iodoamphetamine cerebral blood flow (IMP-CBF) SPECT in regards to early diagnosis of Alzheimer’s disease (AD) in patients with mild cognitive impairment (MCI). Methods Three hundred and nineteen patients with amnestic MCI at 41 participating institutions each Electronic supplementary material The online version of this article (doi:10.1007/s12149-013-0768-7) contains supplementary material, which is available to authorized users. K. Ito (&) J-COSMIC Study Group Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 35 Gengo Morioka-cho, Obu-shi, Aichi 474-8511, Japan e-mail: [email protected] E. Mori Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University, Sendai, Japan H. Fukuyama Human Brain Research Center, Kyoto University, Kyoto, Japan K. Ishii Department of Radiology, Kinki University, Osakasayama, Japan Y. Washimi Department of Outpatient Services, National Center for Geriatrics and Gerontology, Obu, Japan T. Asada Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
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underwent clinical and neuropsychological examinations and 123I-IMP-CBF SPECT at baseline. Subjects were followed up periodically for 3 years, and progression to dementia was evaluated. SPECT images were classified as AD/DLB (dementia with Lewy bodies) pattern and nonAD/DLB pattern by central image interpretation and automated region of interest (ROI) analysis, respectively. Logistic regression analyses were used to assess whether baseline 123I-IMP-CBF SPECT was predictive of longitudinal clinical outcome. Results Ninety-nine of 216 amnestic MCI patients (excluding 3 cases with epilepsy (n = 2) or hydrocephalus (n = 1) and 100 cases with incomplete follow-up) converted to AD within the observation period. Central image S. Mori School of Human Nursing, The University of Shiga Prefecture, Hikone, Japan K. Meguro Department of Geriatric Behavioral Neurology, Tohoku University, Sendai, Japan S. Kitamura Department of Neurology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan H. Hanyu Department of Geriatric Medicine, Tokyo Medical University, To
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