Predictive values of the postoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-m
- PDF / 832,856 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 107 Downloads / 194 Views
(2020) 15:571
RESEARCH ARTICLE
Open Access
Predictive values of the postoperative neutrophil-to-lymphocyte ratio, platelet-tolymphocyte ratio, and lymphocyte-tomonocyte ratio for the diagnosis of early periprosthetic joint infections: a preliminary study Guanglei Zhao, Jie Chen, Jin Wang, Siqun Wang*, Jun Xia, Yibing Wei, Jianguo Wu, Gangyong Huang, Feiyan Chen, Jingsheng Shi, Jinyang Lyu, Changquan Liu and Xin Huang
Abstract Background: Several studies have been conducted to report diagnostic values of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in the many diseases, such as oncological, inflammatory, and some infectious diseases. However, the predictive value of these laboratory parameters for early periprosthetic joint infections (PJIs) has not yet been reported. The aim of this study was to determine predictive values of the postoperative NLR, PLR, and LMR for the diagnosis of PJIs. Methods: In this retrospective study, 104 patients (26 early PJI cases and 78 non-PJI cases) who underwent total joint arthroplasty were enrolled in this study. All the patients were then categorized into two groups: PJI group, patients with the diagnosis of PJI (26 patients; 14 males, 12 females; mean age = 65.47 ± 10.23 age range = 51–81 ) and non-PJI group, patients without PJI (78 patients; 40 males, 38 females; mean age = 62.15 ± 9.33, age range = 41–92). We defined “suspected time” as the time that any abnormal symptoms or signs occurred, including fever, local swelling, or redness around the surgical site between 2 and 4 weeks after surgery and before the diagnosis. Suspected time and laboratory parameters, including NLR, PLR, LMR, erythrocyte sedimentation rate (ESR), and Creactive protein (CRP), were compared between both groups. The trends of postoperative NLR, LMR, PLR, CRP, and ESR were also reviewed. The predictive ability of these parameters at the suspected time for early PJI was evaluated by multivariate analysis and receiver operating characteristic (ROC) curve analysis. (Continued on next page)
* Correspondence: [email protected] Zhao Guanglei and Chen Jie contributed equally to this study. Department of Orthopedics, Huashan Hospital, Fudan University, No.12 Middle Urumqi Road, Shanghai 200040, China © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission
Data Loading...
