Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive d
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RESEARCH ARTICLE
Open Access
Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessivecompulsive disorder Sayo Hamatani1,2, Aki Tsuchiyagaito1,3, Masato Nihei1, Yuta Hayashi4,5, Tokiko Yoshida1, Jumpei Takahashi1, Sho Okawa5,6, Honami Arai1, Maki Nagaoka1, Kazuki Matsumoto1, Eiji Shimizu1,4,7 and Yoshiyuki Hirano1*
Abstract Background: Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERPbased CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT. Methods: Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses. Results: Multiple regression analyses showed that among independent variables, communication as an AQ subscale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT . Conclusions: Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD. Trial registration: UMIN, UMIN00024087. Registered 20 September 2016 - Retrospectively registered (including retrospective data). Keywords: Obsessive-compulsive disorder, Exposure and response prevention, Cognitive behavioral therapy, Therapeutic response
* Correspondence: [email protected] 1 Research Center for Child Mental Development, Chiba University, Inohana, Chuo-ku, Chiba 2608670, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The C
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