Prefoldins: the new chaperones
This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of
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Nabil Djouder Editor
Prefoldins: the new chaperones
Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Nabil Djouder Editor
Prefoldins: the new chaperones
Editor Nabil Djouder Centro Nacional de Investigaciones Oncológicas CNIO, Madrid, Spain
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-00736-2 ISBN 978-3-030-00737-9 (eBook) https://doi.org/10.1007/978-3-030-00737-9 Library of Congress Control Number: 2018961388 © Springer Nature Switzerland AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
“In Memory of Prof. Dr. Wilhelm Krek (February 1st, 1962 to August 29th, 2018)” Dr. Wilhelm Krek discovered and cloned the URI prefoldin-like complex. This book will be a great dedication and recognition of his work.
Preface
Just over 20 years ago, the group of Cowan and colleagues reported on the discovery of the heterohexameric chaperone protein, named prefoldin, based on its ability to bind unfolded proteins and direct them toward folding pathways. Prefoldin facilitates the escort of nonnative proteins to group II chaperonins, found in the eukaryotic cytosol and in archaea, as to promote folding of nascent or misfolded proteins most probably in response to cellular stress. Two years later, Siegert et al. des
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