Prenatal and Preimplantation Diagnosis The Burden of Choice

This book aims to expand the awareness and understanding of the emotional sequelae of prenatal/preimplantation diagnosis, prenatal decision-making, pregnancy interruption for fetal anomaly, multifetal reduction for high-order multifetal pregnancies, and p

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Prenatal and Preimplantation Diagnosis

Joann Paley Galst • Marion S. Verp Editors

Prenatal and Preimplantation Diagnosis The Burden of Choice

Editors Joann Paley Galst, PhD New York, NY, USA

Marion S. Verp, MD Department of Obstetrics and Gynecology The University of Chicago Chicago, IL, USA Department of Human Genetics The University of Chicago Chicago, IL, USA

ISBN 978-3-319-18910-9 DOI 10.1007/978-3-319-18911-6

ISBN 978-3-319-18911-6

(eBook)

Library of Congress Control Number: 2015945168 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

This book is dedicated to my 3-Ds who have influenced my life in immeasurable ways. JPG To my children and grandchildren whose love and support have meant everything. May they always have choices. MSV

Preface

In the past, a woman became pregnant and gave birth to a baby, navigating the pregnancy with little or no information about the fetus and unaware of problems that might be present until after delivery. More recently, thanks to advances in genetics, it has become possible to sequence individual human genomes and detect in a preimplanted embryo or a fetus the presence or absence of not only entire chromosomes but also single nucleotide variations. We have entered an era of rapidly expanding options for noninvasive prenatal screening and testing. Safe, reliable, and inexpensive screening is now available to women early in pregnancy as an alternative to invasive procedures such as amniocentesis and chorionic villus sampling. As a result of the availability of multiple options for prenatal information gathering, women and their partners are increasingly faced with decisions regarding whether to undergo preimplantation or prenatal screening and if so, which methods to choose. Screening b