Preparation and Characterization of Chitosan/Fish Scale Collagen/Lovastatin Nanocomposites
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ORIGINAL PAPER
Preparation and Characterization of Chitosan/Fish Scale Collagen/ Lovastatin Nanocomposites Trang Do Mai Tran1 · Chinh Thuy Nguyen1,2 · Tham Quang Do1 · Giang Long Bach3 · Nghia Hoang Trinh4 · Trung Quoc Vu5 · Hoang Thai1,2
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this study, a polymeric drug delivery system based on chitosan and fish scale collagen was fabricated in the nanometer size by the emulsification method for loading lovastatin drug—a poorly water soluble drug for the treatment of reduction of cholesterol concentration in blood. An interesting point of this work is using collagen extracted from fresh water fish scales. The characteristics, properties, morphology and drug release control ability of the chitosan/collagen/lovastatin nanocomposites were evaluated by Infrared spectroscopy (IR), Field emission scanning electron microscopy (FESEM), Dynamic light scattering (DLS) and Ultraviolet–Visible spectroscopy (UV–Vis) methods. The obtained results showed that the chitosan/ collagen/lovastatin nanocomposites are in spherical shape with the size of particles ranged from 72.1 to 444.0 nm. The chitosan/collagen system can improve the solubility and bioavailability of lovastatin in simulated gastric and intestine fluids. The drug release mechanism from chitosan/collagen/lovastatin nanocomposites was complied with the Korsmeyer-Peppas model. In addition, the in vivo test on mice of chitosan/collagen/lovastatin nanocomposites to investigate their toxicity was conducted and discussed.
* Chinh Thuy Nguyen [email protected] * Hoang Thai [email protected] 1
Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18, Hoang Quoc Viet, Cau Giay, Ha Noi 100000, Vietnam
2
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 100000, Vietnam
3
Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City 700000, Vietnam
4
Military Technical Academy, 236 Hoang Quoc Viet, Bac Tu Liem, Ha Noi 100000, Vietnam
5
Faculty of Chemistry, Hanoi National University of Education, No. 136 Xuan Thuy Road, Cau Giay, Ha Noi 100000, Vietnam
13
Vol.:(0123456789)
Journal of Polymers and the Environment
Graphic Abstract
Keywords Lovastatin · Fish scale collagen · Chitosan · Bioavailability · Kinetic models · Toxicity
Introduction Cholesterol is an indispensable component in the process of hormones synthesizing and cells structuring in the body. However, if the concentration of cholesterol rises above the allowed level, it will cause many serious illnesses, especially obesity and cardiovascular disease including dyslipidemia, coronary artery disease, myocardial infarction, heart failure, etc. [1–3]. This is due to the buildup of excess cholesterol, which creates plaque in the anteries, stimulating the formation of blood clot and causing clogged arteries. Cholesterol can be formed from a variety of sources, including endogenous or exogenous so
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