Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone de
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Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone defect Yumin Zhang . Jianru Wang . Jue Wang . Xiaojun Niu . Jianchun Liu . Lan Gao . Xiaoyan Zhai . Kaibo Chu
Received: 15 December 2014 / Accepted: 16 April 2015 Ó Springer Science+Business Media Dordrecht 2015
Abstract Bone substitutes are used in wide range of orthopaedic application. An ideal bone substitute should exhibit superior osteoinductive and osteoconductive properties. Neither bio-derived materials nor synthetic materials can meet the needs of an ideal bone substitute. Preparation of composite materials is a promising way to improve properties of biomaterial. In this study, the porous poly lactic acid (PLA)/ demineralized bone matrix (DBM) composite biomaterials prepared by supercritical CO2 technique were implanted to repair rabbit radius segmental bone defect. By comparing with PLA and bone autograft, the X-ray result and histological analysis showed the repair effect of PLA/DBM porous composite materials is significantly better than that of the PLA group and the blank control group, and is similar to autologous bone. The PLA/DBM can promote the healing of bone defects and can be used as a kind of ideal alternative materials to repair bone defects. Keywords Composite biomaterials Bone allograft Poly lactic acid Supercritical CO2
Y. Zhang (&) J. Wang X. Niu J. Liu L. Gao X. Zhai K. Chu Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China e-mail: [email protected] J. Wang Shanxi Medical University, Taiyuan, Shanxi, China
Introduction Bone defects may result secondary to the treatment of a variety of pathologies, including traumatic injury and benigh and malignant bone tumors. Bone defect repair is an important topic for the orthopedic surgeon (Sidell et al. 2012). An ideal bone substitute material is crucial to the success of bone defect repair. Bone autografts have the distinct advantage of histocompatibility without the risk of disease transfer and are considered the optimal material for bone repair. However, their limited availability necessitates the development of alternative bone substitutes (Kim et al. 2006). Bone substitute materials applied widely in clinic include bio-derived materials (such as bone allograft, bone xenograft) and synthetic materials (such as HA, PLA, PGA, Calcium Sulfate). However, application of neither meets the needs of an ideal bone substitute due to the instinct disadvantages. It is very valuable to prepare a kind of composite materials with good osteoinduction, osteoconduction and biocompatibility. Bone allograft has been widespread applied in bone regeneration with good osteoinduction and osteoconduction. It is thought to be the best ideal substitute of bone autograft owing to its chemical components and physical structure similarity to the bone autograft. Approximately one-third of the bone grafts used in North America are allografts (Campana et al. 2014). However, the clinical application of bone allografts,
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