Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors
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ORIGINAL ARTICLE
Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors Johanna Mariegaard 1 & Jonathan Wenstrup 2,3,4 & Kevin Zi Ming Lim 3,5 & Pernille Envold Bidstrup 3 & Annika von Heymann 6 & Christoffer Johansen 6 & Gitte Moos Knudsen 1,5 & Ian Law 7 & Lena Specht 2 & Dea Siggaard Stenbæk 1 Received: 4 August 2020 / Accepted: 23 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose This study sought to investigate the prevalence of self-reported cognitive impairment and its relation to illness and treatment characteristics and mental health in Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL) survivors as cancer-related cognitive impairment has not been extensively studied in lymphoma survivors. Methods One hundred fifteen HL and DLBCL survivors (mean age = 40.3 years, mean months since completed treatment = 29.6) completed questionnaires on executive function and mental health. We examined the prevalence of executive impairment and compared illness and treatment characteristics and mental health across survivors reporting impaired and non-impaired executive functioning using chi-square, Cochran-Armitage, and Mann-Whitney U tests. Results We found that 39% reported executive impairment. Survivors reporting impaired executive functioning reported worse mental health (ps < .001) than survivors reporting non-impaired executive functioning. A larger proportion of the impaired group had received a high chemo dose compared to the non-impaired group although this result fell short of significance after adjustment for multiple comparisons (p = .017). Conclusions Self-reported cognitive impairment is prevalent in HL and DLBCL survivors and is associated with worse mental health and possibly high chemo dose. Future studies should investigate objective impairment and the possible dose-response relationship between chemo dose and cognitive impairment in lymphoma survivors. Keywords Cancer-related cognitive impairment . Hodgkin lymphoma . Diffuse large B cell lymphoma . Self-reported cognitive function . Mental health
Introduction In recent years, a growing body of research has emerged on cancer-related cognitive impairment. Subjective complaints often encompass a “mental fog” impacting memory,
* Dea Siggaard Stenbæk [email protected] 1
Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark
2
Department of Oncology, Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark
3
Psychological Aspects of Cancer, Survivorship Unit, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark
concentration, and multi-tasking and may interfere with survivors’ ability to return to their normal life after cancer [1–3]. The majority of studies in this field have been conducted in breast cancer survivors [4], but evidence is emerging that lymphoma survivors may also suffer from self-reported and
4
Department of Neurology, Bispebjerg-Frederiksberg Hospital, DK-2400 Co
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