Primary Sclerosing Cholangitis Current Understanding, Management, an
This text provides a state-of-the art review of primary sclerosing cholangitis (PSC). The volume focuses on new data about the risk factors for PSC, its natural history of the disease, and the epidemiology and genetics of PSC, while providing a
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Primary Sclerosing Cholangitis Current Understanding, Management, and Future Developments
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Primary Sclerosing Cholangitis
Lisa M. Forman Editor
Primary Sclerosing Cholangitis Current Understanding, Management, and Future Developments
Editor Lisa M. Forman Department of Gastroenterology-Hepatology University of Colorado 1635 Aurora Court, B-154 Aurora, CO 80045 USA
ISBN 978-3-319-40906-1 ISBN 978-3-319-40908-5 DOI 10.1007/978-3-319-40908-5
(eBook)
Library of Congress Control Number: 2016959029 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature
Preface
Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments grew out of a need I perceived within the fields of hepatology and liver transplantation. Primary sclerosing cholangitis (PSC) is a rare disease, with an incidence ranging from 0.04 to 1.30 per 1000,000 person years. Patients with PSC have variable presentations and there is significant variability in progression and prognosis. As a clinician, it has been frustrating that up until recently there has been little we could offer patients with PSC, other than liver transplantation, and little that we knew about its pathogenesis. In the liver community, much effort has been made into finding a cure for hepatitis C, a much more common chronic liver disease. With the development of successful antiviral therapies for hepatitis C, there has been a renewed interest into potential treatments of cholestatic diseases. Indeed, it is an exciting time for PSC. Great work has been done to further clarify the role of genetics, immunology, and the microbiome with regard to the development and progression of PSC. Although liver transplantation remains the definitive treatment for advanced PSC, there are multiple new agents that are in clinical trials which will hopefully halt and even improve the fibrosis and subs
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