Primordial odontogenic tumor: a case report and literature review
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CASE REPORT
Open Access
Primordial odontogenic tumor: a case report and literature review Qiaochu Sun1, Jae-Seo Lee2, Okjoon Kim1 and Young Kim1*
Abstract Background: A primordial odontogenic tumor (POT) is a rare, benign, mixed epithelial and mesenchymal odontogenic tumor that has been included as a new entity in the latest World Health Organization (WHO) classification (2017). POT consists of dental papilla-like myxoid connective tissue covered with a delicate membrane of ameloblastic epithelium. Only 15 cases have been documented worldwide, and here, we report the sixteenth case and the first one of South Korea. Case presentation: An asymptomatic lesion was discovered as an incidental radiographic finding in a 10-year-old boy. The patient had no complaints about the lesion. Cone-beam computerized tomograms revealed a round cavity with a defined cortical border measuring approximately 5 × 5 × 5 mm in size. The lesion was a POT. The patient was treated with enucleation. The tumor showed no recurrence for one year. Conclusion: This is the first report of POT in South Korea using the novel diagnosis of POT after it was recognized and defined in the latest WHO classification. This novel diagnosis will be useful for pathologists and clinicians in diagnosing and differentiating this new and rare disease from other odontogenic tumors. Keywords: Primordial odontogenic tumor, Odontogenic tumors, Odontogenesis
Background A primordial odontogenic tumor (POT) is a new entity classified as a benign, mixed odontogenic tumor in the fourth edition of the World Health Organization (WHO) classification of Head and Neck Tumors in 2017 [1]. Mosqueda-Taylor et al. (2014) analyzed the clinicopathological and immunohistochemical features in a series of six cases that did not fulfill the previous criteria for odontogenic tumors [2], and the term “primordial odontogenic tumor” was first used to describe the novel lesion. To date, most cases of POT were found as well-defined unilocular or multilocular radiolucent lesions adjacent to the crown of an unerupted tooth. Patients showed asymptomatic bone swelling, producing root resorption, and buccal or lingual cortical expansion. Macroscopically, the tumor is a pale, slippery, solid nodule that tends to be encapsulated [2, 3]. Histopathologically, POTs consist of variably cellular-to-loose fibrous tissue with dental papilla-like areas, entirely enveloped * Correspondence: [email protected] 1 Department of Oral Pathology, School of Dentistry, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea Full list of author information is available at the end of the article
in a cuboidal-to-columnar epithelium and resembling the inner epithelium of the enamel organ [2]. BolognaMolina et al. investigated the possible histogenesis and biological behavior of POTs using various immunohistochemical methods and suggested that POT is a benign, odontogenic tumor that develops during the primordial stage of tooth development [4]. Until now, only 15 cases have been docum
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