Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical
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ORIGINAL ARTICLE
Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical Study Jalal Moludi 1,2 & Somaieh Saiedi 3 & Behzad Ebrahimi 4 & Mohammad Alizadeh 5 & Yaser Khajebishak 4 & Sevda Saleh Ghadimi 5 Received: 31 March 2020 / Accepted: 14 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Adverse cardiac remodeling after myocardial infarction (MI) can lead to the syndrome of heart failure (HF). Recently, changes in gut microbiota composition (dysbiosis) have appeared as a novel candidate that may be linked to the development of CR and HF. The aim of this trial was to evaluate the effects of probiotics administration on attenuating CR in patients with MI. A single-center double-blind placebo-controlled stratified randomized clinical study was conducted in 44 subjects with MI who underwent percutaneous coronary intervention (PCI). Patients were randomly assigned to take, with lunch, either a probiotic capsule containing 1.6 × 109 colony-forming unit (CFU) of bacteria (treatment group) or capsules contained inulin (control group) over 3 months. CR biomarkers (including serum procollagen III, transforming growth factor beta (TGF-β), trimethylamine N-oxide (TMAO), and matrix metallopeptidase 9 (MMP-9)) were assessed. Echocardiography results were measured at baseline and after the intervention. Significant decreases were seen in serum TGF-β concentrations (− 8.0 ± 2.1 vs. − 4.01 ± 1.8 pg/mL, p = 0.001) and TMAO levels (− 17.43 ± 10.20 vs. − 4.54 ± 8.7 mmol/L, p = 0.043), and there were no differences were seen in MMP-9 (− 4.1 ± 0.12 vs. − 4.01 + 0.15 nmol/mL, p = 0.443) and procollagen III levels (− 1.35 ± 0.70 vs. 0.01 + 0.3 mg/L, p = 0.392) subsequent to probiotics supplementation compared with the placebo group. Improvements in echocardiographic indices were also greater in the probiotics group as compared with that in the control group, but not at a significant level. Regression analysis revealed that baseline left ventricular ejection fraction (LVEF), and changes of procollagen III, predicted 62% of the final LVEF levels. Probiotics administration may have a beneficial effect on the cardiac remodeling process in patients with myocardial infarction. Iranian Registry of Clinical Trials (IRCT): IRCT20121028011288N15 Associate Editor Marat Fudim oversaw the review of this article * Jalal Moludi [email protected] * Mohammad Alizadeh [email protected] 1
School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
2
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
3
Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
4
Maragheh University of Medical Sciences, Maragheh, Iran
5
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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