Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants
- PDF / 942,211 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 50 Downloads / 184 Views
ORIGINAL ARTICLE
Prognostic factors in patients with glioblastoma multiforme: focus on the pathologic variants Ehsan Alimohammadi1 · Seyed Reza Bagheri1 · Alireza Sadeghsalehi1 · Parisa Rizevandi1 · Zahra Rezaie1 · Alireza Abdi1 Received: 22 April 2019 / Accepted: 11 June 2019 © Belgian Neurological Society 2019, corrected publication July 2019
Abstract The aim of this study was to offer predicting factors for survival in adult patients with glioblastoma multiforme. 153 consecutive patients with high-grade glioma (WHO grade IV) were studied in Imam Reza hospital, Kermanshah University of Medical Science, Kermanshah, Iran, between April 2003 and April 2017. All patients treated with surgical resection and standard postoperative radiotherapy (54 Gy). Using the patients’ charts and electronic medical records system, the following data were obtained: gender, age, Karnofsky performance status (KPS) score on admission, primary vs. secondary type, extent of surgery, tumor location, tumor size, necrosis size, use of Temozolomide (TMZ), pathology subtype, and immunohistochemistry results. Patients were followed from the time of the surgery until the death occurred. Overall survival (OS) and progression-free survival (PFS) were calculated by the Kaplan–Meier method. Survival time curves for various subgroups were compared by the log-rank test. The impact of the suggested prognostic factors on survival was evaluated by univariate and multivariate analyses. Age, gender, KPS, extent of surgery, tumor location, necrosis size, and reoperation in recurrence had not any statistically significant effect on survival. Univariate analysis revealed a significant impact on outcome for pathology subtype (PFS: P
Data Loading...
