Prognostic implications of pre-existing medical comorbidity in Takotsubo cardiomyopathy
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ORIGINAL ARTICLE
Prognostic implications of pre‑existing medical comorbidity in Takotsubo cardiomyopathy Arash Nayeri1 · Alexander Yuen1 · Cher Huang1 · Kathryn Cardoza2 · Kamran Shamsa1 · Boback Ziaeian · Quinn S. Wells3,4 · Gregg Fonarow1 · Tamara Horwich1 Received: 29 May 2020 / Accepted: 9 October 2020 © Springer Japan KK, part of Springer Nature 2020
Abstract Takotsubo cardiomyopathy (TC) is associated with significant short-term morbidity and mortality. Several risk factors for poor outcomes have been identified; however, the prognostic implications of pre-existing comorbidity in TC are poorly delineated. We sought to assess the association of aggregate pre-existing comorbidity with short-term outcomes in TC. We performed a retrospective observational study of adult subjects diagnosed with TC at two academic tertiary care hospitals between 2005 and 2018. Overall burden of medical comorbidity was estimated using the Charlson comorbidity index (CCI). Multivariable logistic regression was used to test for independent association of CCI with 30-day mortality and severe shock at index presentation. Multivariable poisson regression was performed to assess the association of CCI with duration of hospitalization. Five-hundred and thirty-eight subjects were diagnosed with TC during the study period. The median CCI score of all subjects was 2 (IQR 1–4). Among subjects with physical triggers of TC, the median CCI score was 2 (IQR 1–4) compared to a median CCI score of 1 (IQR 0–1) in subjects with non-physical triggers of TC (P
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