Prognostic importance of coincidental coronary artery calcification on FDG-PET/CT oncology studies
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ORIGINAL PAPER
Prognostic importance of coincidental coronary artery calcification on FDG‑PET/CT oncology studies Huda El Mais1 · Robert Kay1 · Hassan Almubarak2 · Jennifer M. Rowe3 · Alyssa L. S. Chow4 · Terrence Ruddy1 · Rob S. Beanlands1 · Andrew M. Crean1 · Benjamin J. W. Chow1 · Eugene C. Y. Leung2 · Gary R. Small1,5 Received: 26 October 2020 / Accepted: 16 November 2020 © Springer Nature B.V. 2020
Abstract Coronary artery calcification (CAC) on body CT imaging is considered a coincidental finding in cancer patients. In order to determine the significance of CAC in cancer patients we evaluated the prognostic utility of CAC detected on oncology FDGPET/CT studies. A retrospective study was performed of consecutive FDG-PET/CT studies from January to March 2011. CAC was identified on the CT portion of FDG/PET-CT studies. Chart review documented statin use, the Framingham risk score (FRS) (includes age, diabetes, hypertension, dyslipidemia and smoking), the primary malignancy and metastases. The primary end point was a composite of death and cardiovascular (CV) events (non-fatal myocardial infarction (MI), PCI or coronary artery bypass surgery (CABG)). 266 patients had a median follow up of 41 months (95% CI 31–56 months). CAC was noted in 140 patients. Based on CAC, potentially 84 patients would have had a change in statin prescribing (p
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