Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the
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COMMENTARY
Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group Dimitrios Velissaris . George Dimopoulos . John Parissis . Zoi Alexiou . Nikolaos Antonakos . Dimitrios Babalis . Styliani Gerakari . Vassileios Kaldis . Pantelis Koutoukas . Malvina Lada . Konstantinos Leventogiannis . Ioannis Pantazopoulos . Antonios Papadopoulos . Eftihia Polyzogopoulou . Charalambos Gogos . Apostolos Armaganidis . Evangelos J. Giamarellos-Bourboulis Received: March 5, 2020 The Author(s) 2020
ABSTRACT In light of the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (suPAR), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases frame a position
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statement on the role of suPAR in the screening of patients admitted to the emergency department. The statement is framed taking into consideration existing publications and our own research experience. The main content of this statement is that sUPAR is a non-specific marker associated with a high negative predictive value for unfavourable outcomes; levels \ 4 ng/ml indicate that it is safe to discharge the patient, whereas levels [ 6 ng/ml are an alarming sign of risk for unfavourable outcomes.
D. Velissaris C. Gogos Department of Internal Medicine and Department of Emergency Medicine, University of Patras, Patras, Greece
D. Babalis Department of Emergency Medicine, Larissa General Hospital Koutlibaneion-Triantafyllion, Larissa, Greece
G. Dimopoulos A. Armaganidis Second Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece
S. Gerakari Department of Emergency Medicine, Tzaneion Piraeus General Hospital, Piraeus, Greece
J. Parissis E. Polyzogopoulou Department of Emergency Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece Z. Alexiou Second Department of Internal Medicine, Thriasio Elefsis General Hospital, Elefsina, Greece N. Antonakos K. Leventogiannis A. Papadopoulos E. J. Giamarellos-Bourboulis (&) Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece e-mail: [email protected]
V. Kaldis Department of Emergency Medicine, Sismanogleion Athens General Hospital, Athens, Greece P. Koutoukas Department of Emergency Medicine, Sparti General Hospital, Sparti, Greece M. Lada Second Department of Internal Medicine, Sismanogleion General Hospital, Athens, Greece I. Pantazopoulos Department of Emergency Medicine, University General Hospital of Larissa, School of Medicine, University of Thessaly, Larisa, Greece
Infect Dis Ther
However, the suPAR levels should always be interpreted in light of the patient’s history.
Keywords: Emergency department; Mortality; suPAR; Triage Key Sum
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