Prognostic significance of regional edema and quantitative assessment of late gadolinium enhancement in patients with ac
- PDF / 183,184 Bytes
- 1 Pages / 595.276 x 793.701 pts Page_size
- 56 Downloads / 183 Views
POSTER PRESENTATION
Open Access
Prognostic significance of regional edema and quantitative assessment of late gadolinium enhancement in patients with acute myocarditis Emmanuelle Vermes*, Helene Childs, Matthias G Friedrich From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Background Standard diagnostic CMR criteria for acute myocarditis have been proposed (ie Lake Louise criteria) based upon the any 2 of 3 approach which includes the presence of myocardial edema (T2), hyperemia/capillary leakage (early Gd enhancement: EGE) as well as fibrosis (late enhancement: LGE). However, there is a lack of prognostic data using these criteria. The aim of this study was to evaluate the diagnostic CMR criteria for the prediction of functional outcome in patients with myocarditis. Methods We studied 24 patients referred for acute myocarditis during the acute phase and 1 year thereafter. CMR studies included T2 weighted and contrast-enhanced T1 weighted (early and late enhancement) with a quantitative assessment of the regional and LGE. Results In the acute phase, edema (regional and /or global) was present in 67%, EGE in 62.5% and LGE in 54%. Edema %LV (2SD) was: 27.3±7.8; LGE %LV (2SD) was 20.5 ±14.2. At follow-up, EF significantly increased from 57± 5.5% to 60± 4.5% (p< 0.001). In a univariate analysis, LGE% LV was correlated to the change in EF over 1-year (r=0.704, p=0.04), in a multivariate analysis (linear regression), the combination of LGE%LV and regional edema serves as an independent predictor of an increase of EF (F=5.13, p=0.017)
Conclusion In our preliminary experience, the combination of LGE with regional edema was an independent predictor of functional recovery during a 1 year follow-up. Published: 2 February 2011
doi:10.1186/1532-429X-13-S1-P179 Cite this article as: Vermes et al.: Prognostic significance of regional edema and quantitative assessment of late gadolinium enhancement in patients with acute myocarditis. Journal of Cardiovascular Magnetic Resonance 2011 13(Suppl 1):P179.
Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution
Calgary, calgary, AB, Canada Full list of author information is available at the end of the article
Submit your manuscript at www.biomedcentral.com/submit
© 2011 Vermes et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Data Loading...
