Prognostic Value of Melanoma-Associated Antigen-A ( MAGE-A ) Gene Expression in Various Human Cancers: A Systematic Revi
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SYSTEMATIC REVIEW
Prognostic Value of Melanoma‑Associated Antigen‑A (MAGE‑A) Gene Expression in Various Human Cancers: A Systematic Review and Meta‑analysis of 7428 Patients and 44 Studies Manish Poojary1 · Padacherri Vethil Jishnu1 · Shama Prasada Kabekkodu1
© The Author(s) 2020
Abstract Background Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence. Objective This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers. Methods A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science. The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers. Results In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P
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