Progression of Vasculopathy in Young Individuals with Turner Syndrome
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ORIGINAL ARTICLE
Progression of Vasculopathy in Young Individuals with Turner Syndrome Christopher E. Blunden1,3 · Elaine M. Urbina2 · Sarah A. Lawson1 · Iris Gutmark‑Little1 · Amy S. Shah1 · Philip R. Khoury2 · Philippe F. Backeljauw1 Received: 25 May 2020 / Accepted: 17 November 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Vasculopathy has been identified in young individuals with Turner syndrome (TS). No studies in young individuals with TS have investigated whether this vasculopathy progresses over time. The objective of this study is to describe the changes in vasculopathy over time in a cohort of young individuals with TS. Repeat ultrasound and SphygmoCor CPV® (AtCor Medical) measurements of carotid thickness and peripheral arterial stiffness were performed. Vascular measurements were compared at baseline and follow-up. Follow-up measurements were also compared to historical lean (L) and obese (O) age-, race-, and sex-matched non-TS controls. Thirty-five individuals with TS were studied at a mean age of 19.4 years (range, 13.9–27.5). Mean time to follow-up was 7.2 years (range, 7.1–7.8). Carotid intima media thickness increased by 0.03 ± 0.07 mm (p
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