Properties and temporal dynamics of choice- and action-predictive signals during item recognition decisions
- PDF / 1,425,667 Bytes
- 16 Pages / 595.276 x 790.866 pts Page_size
- 86 Downloads / 175 Views
ORIGINAL ARTICLE
Properties and temporal dynamics of choice‑ and action‑predictive signals during item recognition decisions Roberto Guidotti1 · Annalisa Tosoni1 · Carlo Sestieri1 Received: 9 January 2020 / Accepted: 24 July 2020 / Published online: 9 August 2020 © The Author(s) 2020
Abstract Decision-making is in the service of action regardless of whether the decision concerns perceptual information, goods or memories. Compared to recent advances in the neurobiology of perceptual or value-based decisions, however, the neural bases supporting the sampling of evidence in long-term memory, and the transformation of memory-based decisions into appropriate actions, are still poorly understood. In the present fMRI study, we used multivariate pattern analysis to investigate the temporal dynamics of choice- and action-predictive signals during an item recognition task that manipulated the association between memory choices (old/new) and motor responses (eye/hand) across subjects. Choice-predictive activity was mainly observed in striatal, lateral prefrontal and lateral parietal regions, was sensitive to the amount of decision evidence and showed a rapid increase after stimulus onset, followed by a fast decay. Action-predictive signals were found in primary sensory motor, premotor and occipito–parietal regions, were generally observed at the end of the decision phase and were not modulated by decision evidence. These findings suggest that a memory decision variable, potentially represented in a fronto–striato–parietal network, is not directly transformed into an action plan as often observed in perceptual decisions. Regions exhibiting choice predictive activity, and especially the striatum, however, also showed a second peak of decisionrelated activity that, unlike pure choice- or action-predictive signals, depended on the particular choice–response association. This second peak of activity in the striatum might represent the neural signature of the transformation of a memory decision into an appropriate motor response based on the specific choice–response association. Keywords Episodic memory · Item recognition · Decision-making · Motor intention · MVPA
Introduction Decision-making involves the evaluation of evidence for a particular choice and the selection of an appropriate action (Kable and Glimcher 2009; Shadlen and Shohamy 2016). While perceptual and value-based decisions are emblematic of this strong sensori-motor chain, the association between decisions and actions can be less evident in other contexts. However, also decisions based on information stored in long-term memory can directly inform actions, such as Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00429-020-02124-4) contains supplementary material, which is available to authorized users. * Carlo Sestieri [email protected] 1
Department of Neuroscience, Imaging and Clinical Sciences, ITAB Institute for Advanced Biomedical Technologies, G. D’Annunzio University of Chieti-Pescara, 66100 Chieti, Ital
Data Loading...
