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Propofol infusion syndrome: case report A 40-year-old man developed propofol infusion syndrome (PRIS) during treatment with propofol for postoperative pain, restlessness and anxiety. Additionally, the treatment with unspecified glucocorticoids also contributed in the development of PRIS. The man, who had obstructive sleep apnea syndrome was admitted and undergone tonsillectomy and early surgical exploration. During the postoperative period, he started receiving treatment with propofol infusion up to 2 mg/kg/hour for 10 hours, along with midazolam, remifentanil and tramadol. Additionally, he was administered with low doses of unspecified glucocorticoids [glucocorticosteroids] and unspecified third-generation cephalosporin. After the initiation of propofol, electrocardiogram revealed mild prolongation of the QT interval with notched T-waves mainly in peripheral leads. Labortaory investigation showed increased level of lactic acid in blood. These findings were consistent with PRIS associated with propofol [duration of treatment to reaction onset not stated]. The man’s treatment with propofol was discontinued. Within 2 hours, the electrocardiogram changes disappeared and lactic acid normalised within 24 hours. Additionally, a slightly increase in creatine kinase was observed. Dell’Angela L, et al. Propofol Infusion Syndrome: An Early and Unusual Electrocardiographic Pattern. Journal of Cardiothoracic and Vascular Anesthesia 34: 2004-2006, No. 803497922 7, Jul 2020. Available from: URL: http://doi.org/10.1053/j.jvca.2019.10.033

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Reactions 22 Aug 2020 No. 1818