Proprotein Convertases
Today, activation endoproteolysis of secretory proteins is recognized as a fundamental biological mechanism of spatial and temporal regulation of protein activity as well as of diversification of protein functions. In Proprotein Convertases, experts
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MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
TM
Proprotein Convertases
Edited by
Majambu Mbikay Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Nabil G. Seidah Biochemical Neuroendocrinology Laboratory, Clinical Research Institute of Montreal (IRCM), Montreal, QC, Canada
Editors Majambu Mbikay Chronic Disease Program Ottawa Hospital Research Institute K1Y 4E9 Ottawa, ON, Canada [email protected]
Nabil G. Seidah Biochemical Neuroendocrinology Laboratory Clinical Research Institute of Montreal (IRCM) H2W 1R7 Montreal, QC, Canada [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-203-8 e-ISBN 978-1-61779-204-5 DOI 10.1007/978-1-61779-204-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011933260 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface This special volume of Methods in Molecular Biology covers precursor endoproteolysis as a mechanism of protein activation/inactivation in the secretory pathway. Initially identified in the late 1960s as a post-translational modification leading to the production of hormonal and neural peptides, this process was found through the years to be an intervening step in the activation, and sometimes inactivation, of a wide variety of functional proteins, in nearly all cells and living organisms, from viruses to mammals. Today, activation endoproteolysis of secretory proteins is recognized as a fundamental biological mechanism of spatial and temporal regulation of protein activity as well as of diversification of protein functions. It is described at varying lengths in most cell biology textbooks written in the last two decades. Proprotein convertases, the enzymes mediating this endoproteolysis, constitute the central theme of this volume. These endoproteinases travel through, reside within, or cycle between the various compartments of the secretory pathway. Most of them are calciumdependent serine proteases of the subtilase subfamily, collectively designated as propro
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