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Propylthiouracil/thiamazole Skin rash and vasculitis: case report In a study, a 48-year-old woman with Graves’ disease with hyperthyroidism commenced treatment with thiamazole.* After 3 weeks of treatment, she developed a skin rash [outcome not stated]. Thiamazole was switched to propylthiouracil,* which was continued for 6 years without complications. After 6 years, she developed vasculitis with ulcerations on her earlobes and nose. She tested positive for myeloperoxidase (MPO)-ANCA. Propylthiouracil was discontinued and prednisone was administered. Her vasculitis resolved and MPO-ANCA became negative. She remained euthyroid after 4 years’ follow-up without medication. * Routes and specific dosages were not stated, but the median dosages of the 108 study participants were thiamazole 5 mg/day and propylthiouracil 200 mg/day. Laurberg P, et al. Sustained control of graves? hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe graves? orbitopathy. Thyroid 21: 951-956, No. 9, Sep 2011. Available from: URL: http:// 803062332 dx.doi.org/10.1089/thy.2011.0039 - Denmark

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Reactions 5 Nov 2011 No. 1376