Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-San
- PDF / 910,780 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 111 Downloads / 181 Views
RESEARCH
Open Access
Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study Emmanuelle Kesse-Guyot1* , Pauline Rebouillat1, Laurence Payrastre2, Benjamin Allès1, Léopold K. Fezeu1, Nathalie Druesne-Pecollo1, Bernard Srour1, Wei Bao3, Mathilde Touvier1, Pilar Galan1, Serge Hercberg1,4, Denis Lairon5 and Julia Baudry1
Abstract Background: Organic food (OF) consumption has substantially increased in high income countries, mostly driven by environmental concerns and health beliefs. Lower exposure to synthetic pesticides has been systematically documented among consumers of organic products compared to non-consumers. While experimental studies suggest that pesticides currently used in food production may be associated with type 2 diabetes (T2D), no well-conducted prospective studies have investigated the potential association between consumption of organic products and the risk of T2D, controlling for potential confounding factors. The objective of this prospective study was to estimate the association between OF consumption and the risk of T2D. Methods: A total of 33,256 participants (76% women, mean (SD) age: 53 years (14)) of the French NutriNet-Santé prospective cohort study who completed the organic food frequency questionnaire were included (2014–2019). The proportion of OF in the diet (as weight without drinking water) was computed. The associations between the proportion of OF in the diet (as 5% increment and as quintiles) and the risk of T2D were estimated using multivariable Hazard Ratio (HR) and 95% confidence interval (95% CI) derived from proportional hazards models adjusted for confounders (sociodemographic, anthropometric, lifestyle, medical and nutritional factors). Results: During follow-up (mean = 4.05 y, SD = 1.03 y, 134,990 person-years), 293 incident cases of T2D were identified. After adjustment for confounders including lifestyle (physical activity, smoking status, alcohol consumption) and nutritional quality of the diet assessed by the adherence to the French food-based dietary guidelines, OF consumption was associated with a lower risk of T2D. Participants with the highest quintile of OF consumption, compared with those with the lowest quintile, had 35% lower risk of T2D (95% CI = 0.43–0.97). Each increment of 5% in the proportion of OF in the diet was associated with 3% lower risk of T2D (HR 0.97, 95% CI = 0.95–0.99). Conclusions: In this large prospective cohort study, OF consumption was inversely associated with the risk of T2D. Further experimental and prospective studies should be conducted to confirm these observations. (Continued on next page)
* Correspondence: [email protected] 1 Sorbonne Paris Nord University, Inserm, Inrae, Cnam, Nutritional Epidemiology Research Team (EREN), Epidemiology and Statistics Research Center – University of Paris (CRESS), F- 93017 Bobigny, France Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This arti
Data Loading...
