Prostacyclin and Hypertension
The aim of present-day treatment of hypertension is no longer as the effective reduction of blood pressure, regarded merely but as the ever-increasing application of new therapeutic prin ciples to prevent such consequences of hypertension as left heart h
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Prostacyclin and Hypertension
With 49 Figures and 4 Tables
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong
Priv.-Doz. Dr. Gerd Bonner Medizinische Universitatsklinik II Stadtische Krankenanstalten Merheim Ostmerheimer StraBe 200 D-5000 Koln 91, FRG Professor Dr. Karl-Heinz Rahn Medizinische Poliklinik der Universitat Miinster Albert-Schweitzer-StraBe 33 D-4400 Miinster, FRG
Translation from the second revised edition in German
ISBN-13: 978-3-540-52140-2 e-TSBN-13: 978-3-642-95608-9 DOl: 10.1007/978-3-642-95608-9
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1990 The use of general descriptive names, registered names, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
IV
Preface to the Second Edition
The aim of present-day treatment of hypertension is no longer regarded merely as the effective reduction of blood pressure, but as the ever-increasing application of new therapeutic principles to prevent such consequences of hypertension as left heart hypertrophy, medial hypertrophy of the vessels and arteriosclerosis. In this context special attention has been directed to stimulation of the endogenous vasocilator hormonal systems such as the prostaglandins. The great interest in our book, which has meanwhile appeared in a French edition, seems to confirm this trend and has encouraged us to include in the book the new findings published in the last twelve months. These changes and additions maintain the current status of the book and provide an even more complete survey of the available information about prostacyclin in hypertension. We wish to thank all those colleagues who have made useful suggestions for this second edition, as well as SpringerVerlag and its associates, who ensured a uniformly smooth passage in the production of the book. Cologne and MUnster, January 1990
Gerd Bonner Karl-Heinz Rahn
v
Preface to the First Edition
Diseases of the heart and circulation currently constitute the commonest causes of death in our population. Hypertension, as evidenced by a pathologic increase in blood pressure, is one of th
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