Prostate Cancer Signaling Networks, Genetics, and New Treatment Stra

Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies

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CURRENT CLINICAL ONCOLOGY Maurie Markman,

MD,

SERIES EDITOR

Integrative Oncology: Incorporating Complementary Medicine into Conventional Cancer Care, edited by LORENZO COHEN AND MAURIE MARKMAN, 2008 Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies, edited by RICHARD G. PESTELL AND MARJA T. NEVALAINEN, 2008 Intraperitoneal Cancer Therapy, edited by WILLIAM C. HELM AND ROBERT EDWARDS, 2007 Molecular Pathology of Gynecologic Cancer, edited by ANTONIO GIORDANO, ALESSANDRO BOVICELLI, AND ROBERT KURMAN, 2007 Colorectal Cancer: Evidence-Based Chemotherapy Strategies, edited by LEONARD B. SALTZ, 2007 High-Grade Gliomas: Diagnosis and Treatment, edited by GENE H. BARNETT, 2006 Cancer in the Spine: Comprehensive Care, edited by ROBERT F. MCLAIN, KAI-UWE LEWANDROWSKI, MAURIE MARKMAN, RONALD M. BUKOWSKI, ROGER MACKLIS, AND EDWARD C. BENZEL, 2006 Squamous Cell Head and Neck Cancer, edited by DAVID J. ADELSTEIN, 2005 Hepatocellular Cancer: Diagnosis and Treatment, edited by BRIAN I. CARR, 2005 Biology and Management of Multiple Myeloma, edited by JAMES R. BERENSON, 2004 Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done, edited by JAMES H. FINKE AND RONALD M. BUKOWSKI, 2004 Treatment of Acute Leukemias: New Directions for Clinical Research, edited by CHING-HON PUI, 2003 Allogeneic Stem Cell Transplantation: Clinical Research and Practice, edited by MARY J. LAUGHLIN AND HILLARD M. LAZARUS, 2003 Chronic Leukemias and Lymphomas: Biology, Pathophysiology, and Clinical Management, edited by GARY J. SCHILLER, 2003 Colorectal Cancer: Multimodality Management, edited by LEONARD SALTZ, 2002 Breast Cancer: A Guide to Detection and Multidisciplinary Therapy, edited by MICHAEL H. TOROSIAN, 2002 Melanoma: Biologically Targeted Therapeutics, edited by ERNEST C. BORDEN, 2002

PROSTATE CANCER Signaling Networks, Genetics, and New Treatment Strategies

Edited by

RICHARD G. PESTELL, MD, PhD MARJA T. NEVALAINEN, MD, PhD Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA

Foreword by

MICHAEL MILKEN, MBA Prostate Cancer Foundation, Santa Monica, CA

Editors Richard G. Pestell Department of Cancer Biology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA

Marja T. Nevalainen Department of Cancer Biology Kimmel Cancer Center Thomas Jefferson University Philadelphia, PA

Series Editor Maurie Markman MD Anderson Cancer Center University of Texas Houston, TX

ISBN 978-1-58829-741-9

e-ISBN 978-1-60327-079-3

Library of Congress Control Number: 2007941659 ©2008 Humana Press, a part of Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, 999 Riverview Drive, Suite 208, Totowa, NJ 07512 USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known o