Protective Effects of Curcumin and N-Acetyl Cysteine Against Noise-Induced Sensorineural Hearing Loss: An Experimental S
- PDF / 222,809 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 82 Downloads / 148 Views
ORIGINAL ARTICLE
Protective Effects of Curcumin and N-Acetyl Cysteine Against Noise-Induced Sensorineural Hearing Loss: An Experimental Study Zeynep I˙skender Emekli1
•
Fatma S¸entu¨rk2
•
Osman Bahadir3
Received: 30 September 2020 / Accepted: 3 November 2020 Ó Association of Otolaryngologists of India 2020
Abstract We investigated the effectiveness of N-acetyl cysteine (NAC) and curcumin, which have known antioxidant and anti-inflammatory effects, in reducing acoustic trauma. We randomly divided 40 adult male rats into four groups: a control group (group 1), a curcumin group (group 2), a NAC group (group 3), and an ethyl alcohol group (group 4). The rats were exposed to 110 dB sound at a frequency of 4 kHz for 2 h to simulate acoustic trauma. Group 1, group 2, group 3, and group 4 received 1 ml saline, 200 mg/kg curcumin, 350 mg/kg NAC, or 1 ml ethyl alcohol, respectively, intraperitoneally 30 min before and 24 and 48 h after acoustic trauma. Distortion product otoacoustic emissions (DPOAEs) were recorded before and after the acoustic trauma, and 72 h after drug administration. In group 2, signal-to-noise ratio (SNR) values in frequencies of 1000 Hz, 1500 Hz, and 4000 Hz decreased in the second measurements when compared to the first, and showed improvements in the third measurements in comparison to the second ones. In group 3, SNR values decreased in the second measurements, but only the values at 6000 Hz were found to be statistically significant (p = 0.007). The values in the third measurements were statistically significant when compared to the second ones. There was a statistically significant difference in the third
& Fatma S¸ entu¨rk [email protected] 1
Department of Otolaryngology, Malatya Training and Research Hospital, Malatya, Turkey
2
Department of Otolaryngology, Bingo¨l Maternity and Children’s Hospital, Bingo¨l-Mus¸ Highway Gayt Bridge Location, 12000 Bingo¨l, Turkey
3
Department of Otolaryngology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
measurements in both groups 2 and 3, possibly due to curcumin and NAC treatment. This study showed that curcumin and NAC may be effective against noise-induced hearing loss. Keywords Acoustic trauma Curcumin Hearing loss N-acetyl cysteine
Introduction Acoustic trauma occurs as a result of damage to hearing mechanisms in the inner ear after exposure to excessive noise ([ 85 dB). Acoustic trauma is the most important cause of noise-related hearing loss in adults [1]. Exposure to high-intensity noise (130 dB SPL) causes direct mechanical damage in hairy cells and support cells in the organ of Corti. As a result of this damage, the biochemical complex cascade is activated in hairy cells and reactive oxygen species (ROS) are formed. Ischemia, exotoxic damage, metabolic fatigue, and ionic imbalance occur in the inner ear fluids [2]. After the development of trauma-induced hypoxia, ROS cannot be removed due to impaired blood circulation and accumulate in tissues. Accumulation of radicals leads to progressive cell dam
Data Loading...
