Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are p
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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany
ASSISTANT EDITOR P. J. QUINN, King’s College London, London, U.K.
INTERNATIONAL ADVISORY BOARD R. Bittman, Queens College, City University of New York, New York, USA D. Dasgupta, Saha Institute of Nuclear Physics, Calcutta, India A. Holzenburg, Texas A&M University College Station, USA S. Rottem, The Hebrew University, Jerusalem, Israel M. Wyss, DSM Nutritional Products Ltd., Basel, Switzerland
For further volumes: http://www.springer.com/series/6515
J. Robin Harris Editor
Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
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Editor J. Robin Harris Institute of Zoology University of Mainz Mainz Germany Institute for Cell and Molecular Biosciences Newcastle University Newcastle UK
ISSN 0306-0225 ISBN 978-94-007-5415-7 ISBN 978-94-007-5416-4 (eBook) DOI 10.1007/978-94-007-5416-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2012953928 © Springer Science+Business Media Dordrecht 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the Editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects, in most cases. Accordingly, the book has been divided into the following sections: I. Introduction, II. Basic Science (12 chapters), III. Clinical Science: the Cerebral and Systemic Diseases (9 Chapters). Internationally-based authoritative authors who are actively involved in their field of study have been selected as contributors to the book. The book starts with an Introductory chapter, by Nathaniel Milton and myself, that also includes a technical survey of the many laboratory-based microscopical, analytical and biophysical, biochemical and cellular approaches used for the study of protein/peptide oligomerization, aggregation and fibrillogenesis. Some emphasis is give to the application of transmission electron
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