Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients
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STUDY PROTOCOL
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Protein delivery in intermittent and continuous enteral nutrition with a proteinrich formula in critically ill patients—a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study Simona Reinhold1†, Desirée Yeginsoy1†, Alexa Hollinger1* , Atanas Todorov1, Lionel Tintignac2, Michael Sinnreich3, Caroline Kiss4, Caroline E. Gebhard1, Balázs Kovács5, Bianca Gysi1, Lara Imwinkelried1 and Martin Siegemund1
Abstract Background: Critically ill patients rapidly develop muscle wasting resulting in sarcopenia, long-term disability and higher mortality. Bolus nutrition (30–60 min period), whilst having a similar incidence of aspiration as continuous feeding, seems to provide metabolic benefits through increased muscle protein synthesis due to higher leucine peaks. To date, clinical evidence on achievement of nutritional goals and influence of bolus nutrition on skeletal muscle metabolism in ICU patients is lacking. The aim of the Pro BoNo study (Protein Bolus Nutrition) is to compare intermittent and continuous enteral feeding with a specific high-protein formula. We hypothesise that target quantity of protein is reached earlier (within 36 h) by an intermittent feeding protocol with a favourable influence on muscle protein synthesis. Methods: Pro BoNo is a prospective randomised controlled study aiming to compare the impact of intermittent and continuous enteral feeding on preventing muscle wasting in 60 critically ill patients recruited during the first 48 h after ICU admission. The primary outcome measure is the time until the daily protein target (≥ 1.5 g protein/kg bodyweight/ 24 h) is achieved. Secondary outcome measures include tolerance of enteral feeding and evolution of glucose, urea and IGF-1. Ultrasound and muscle biopsy of the quadriceps will be performed. Discussion: The Basel Pro BoNo study aims to collect innovative data on the effect of intermittent enteral feeding of critically ill patients on muscle wasting. Trial registration: ClinicalTrials.gov NCT03587870. Registered on July 16, 2018. Swiss National Clinical Trials Portal SNCT P000003234. Last updated on July 24, 2019. Keywords: Nutrition and dietetics, Adult intensive and critical care, Ultrasound
* Correspondence: [email protected] † Simona Reinhold and Desirée Yeginsoy contributed equally to this work. 1 Intensive Care Unit, University Hospital Basel, Basel, Switzerland Full list of author information is available at the end of the article
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