Protein-Protein and Domain-Domain Interactions
This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and ta
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Protein-Protein and DomainDomain Interactions
Protein-Protein and Domain-Domain Interactions
Pandjassarame Kangueane Christina Nilofer
Protein-Protein and Domain-Domain Interactions
Pandjassarame Kangueane Biomedical Informatics Pondicherry, India
Christina Nilofer Biomedical Informatics Pondicherry, India School of Bio Sciences and Technology VIT University Vellore, Tamil Nadu, India
ISBN 978-981-10-7346-5 ISBN 978-981-10-7347-2 (eBook) https://doi.org/10.1007/978-981-10-7347-2 Library of Congress Control Number: 2017964603 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
This book is dedicated to J. Janin, C. Chothia, and R. Nussinov for their scientific contribution in this field and to P. Balaram, C. Ramakrishnan, and P. Gautam for their personal support during this long journey through decades of excitement.
Preface
Protein complexes are often involved in catalysis, regulation, assembly, immunity, and inhibition. This involves the formation of stable interfaces between the interacting proteins. Therefore, it is important to understand the molecular principles of protein-protein binding. This book introduces the concepts in the understanding of protein-protein interaction (PPI) using several illustrations and examples. It illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions toward the understanding of cell division, disease mechanism, and target definition in drug discovery. It describes several issues associated with PPI using cutting-edg
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