Psychological Outcomes of a Cognitive Behavioral Therapy for Youth with Inflammatory Bowel Disease: Results of the HAPPY

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Psychological Outcomes of a Cognitive Behavioral Therapy for Youth with Inflammatory Bowel Disease: Results of the HAPPY‑IBD Randomized Controlled Trial at 6‑ and 12‑Month Follow‑Up Luuk Stapersma1   · Gertrude van den Brink2 · Jan van der Ende1 · Eva M. Szigethy3 · Michael Groeneweg4 · Frederieke H. de Bruijne5 · Manon H. J. Hillegers1 · Johanna C. Escher2 · Elisabeth M. W. J. Utens1,6,7

© The Author(s) 2019

Abstract Youth with inflammatory bowel disease (IBD) often experience psychological difficulties, such as anxiety and depression. This randomized controlled study tested whether a 3-month disease-specific cognitive behavioral therapy (CBT) in addition to standard medical care versus standard medical care only was effective in improving these youth’s psychological outcomes. As this study was aimed at prevention, we included 70 youth (10–25 years) with IBD and symptoms of subclinical anxiety and/ or depression, and measured psychological outcomes at 6- and 12-month follow-up. In general, participants in both groups showed improvements in anxiety, depression, health-related quality of life, social functioning, coping, and illness perceptions, sustained until 12 months follow-up. Overall, we found no differences between those receiving additional CBT and those receiving standard medical care only. We assume that this can be explained by the perceived low burden (both somatically and psychologically) or heightened awareness of psychological difficulties and IBD. ClinicalTrials.gov NCT02265588. Keywords  Inflammatory bowel disease · Adolescents · Young adults · Anxiety · Depression · Psychological outcomes · Cognitive behavioral therapy Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by periods of active inflammation (with increased clinical symptoms) * Elisabeth M. W. J. Utens [email protected] 1



Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children’s Hospital, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands

2



Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

3

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

4

Department of Pediatrics, Maasstad Hospital, Rotterdam, The Netherlands

5

Department of Gastroenterology, Maasstad Hospital, Rotterdam, The Netherlands

6

Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands

7

Academic Center for Child Psychiatry the Bascule/Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands



followed by periods of clinical remission. The two main types of IBD are Crohn’s disease (CD) and ulcerative colitis (UC). Symptoms are abdominal pain, bloody diarrhea, fatigue, fever, and weight loss (Griffiths, 2004; Rose, Dhawan, & Saeed, 2015). Pediatric patients may also show anorexia/loss of appetite, malnutrition, and delayed growth and puberty onset—especially those with CD (Adamiak et al., 2013