Psychopharmacological Medication Has No Influence on Vitamin Status After Bariatric Surgery in Long-term Follow-up

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Psychopharmacological Medication Has No Influence on Vitamin Status After Bariatric Surgery in Long-term Follow-up Hannes Beiglböck 1 & Alexander Kautzky 2 & Paul Fellinger 1 & Tamara Ranzenberger-Haider 1 & Bianca Itariu 1 & Thomas Wrba 3 & Gerhard Prager 4 & Alexandra Kautzky-Willer 1 & Peter Wolf 1 & Michael Krebs 1

# The Author(s) 2020

Abstract Context A substantial number of patients undergoing bariatric surgery are prescribed psychopharmacological medication. However, the impact of concomitant psychopharmacological medication on the frequency of relevant vitamin deficiencies in postoperative follow-up is not known. Methods Five hundred twenty-four patients with obesity who underwent bariatric surgery (January 2004 to September 2018) with follow-up of at least 12 months, were included in retrospective analysis. Postoperative follow-up visits between January 2015 and September 2019 were analyzed. Anthropometric and laboratory data were analyzed at the first documented follow-up visit after on average 39.5 ± 37.3 months and at every following visit during the observation period. Patients with prescribed psychopharmacological drugs (PD) were compared with patients without (control group, CON). Results Psychopharmacological medication was documented in 25% (132) of patients. In 59 patients documented prescription of more than one psychiatric drug was found, whereas psychopharmacological monotherapy was found in 73 patients. Frequencies of vitamin deficiencies were comparable between PD and CON (vitamin A: p = 0.852; vitamin D: p = 0.622; vitamin E: p = 0.901; folic acid: p = 0.941). Prevalence of vitamin B12 deficiency was rare (6% CON, 1% PD) but was significantly higher in CON (p = 0.023). A comparison of CON and POLY also showed no significant differences between the groups concerning prevalence of vitamin deficiencies. Conclusions Intake of psychopharmacological medication is highly prevalent in patients after bariatric surgery. Patients with psychopharmacological medication, who participate in structured follow-up care after bariatric surgery, are not at higher risk for vitamin deficiencies compared with controls. Keywords Bariatric surgery . Vitamins . Psychiatric medication

* Michael Krebs [email protected]

Alexandra Kautzky-Willer [email protected]

Hannes Beiglböck [email protected] Alexander Kautzky [email protected]

Peter Wolf [email protected] 1

Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria

2

Bianca Itariu [email protected]

Department of Psychiatry and Psychotherapy, Division of Social Psychiatry, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria

3

Thomas Wrba [email protected]

IT Systems and Communications, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria

4

Division of General Surgery, Department of Bariat